Age intrinsic loss of telomere protection via TRF1 reduction in endothelial cells
نویسندگان
چکیده
منابع مشابه
Loss of Telomere Protection: Consequences and Opportunities
Telomeres are repetitive sequences at the natural ends of linear eukaryotic chromosomes that protect these from recognition as chromosome breaks. Their ability to do so critically depends on the binding of sufficient quantities of functional shelterin, a six-unit protein complex with specific and crucial roles in telomere maintenance and function. Insufficient telomere length, leading to insuff...
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Britt J. Heidinger, Katherine A. Herborn, Hanna M.V. Granroth-Wilding, Winnie Boner, Sarah Burthe, Mark Newell, Sarah Wanless, Francis Daunt and Pat Monaghan Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Graham Kerr Building, Glasgow G12 8QQ, UK; Institute of Evolutionary Biology and Immunology and Inf...
متن کاملResolution of telomere associations by TRF1 cleavage in mouse embryonic stem cells
Telomere associations have been observed during key cellular processes such as mitosis, meiosis, and carcinogenesis and must be resolved before cell division to prevent genome instability. Here we establish that telomeric repeat-binding factor 1 (TRF1), a core component of the telomere protein complex, is a mediator of telomere associations in mammalian cells. Using live-cell imaging, we show t...
متن کاملControl of human telomere length by TRF1 and TRF2.
Telomere length in human cells is controlled by a homeostasis mechanism that involves telomerase and the negative regulator of telomere length, TRF1 (TTAGGG repeat binding factor 1). Here we report that TRF2, a TRF1-related protein previously implicated in protection of chromosome ends, is a second negative regulator of telomere length. Overexpression of TRF2 results in the progressive shorteni...
متن کاملTRF1 is a critical trans-acting factor required for de novo telomere formation in human cells.
The duplex telomere repeat (TTAGGG)(n) is an essential cis-acting element of the mammalian telomere, and an exogenous telomere repeat can induce chromosome breakage and de novo telomere formation at the site of a break (telomere seeding). Telomere seeding requires the telomere repeat (TTAGGG)(n) more stringently than does an in vitro telomerase assay, suggesting that it reflects the activity of...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2016
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2015.11.034